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Metallothionein Prevents Age-Associated Cardiomyopathy via Inhibiting NF-κB Pathway Activation and Associated Nitrative Damage to 2-OGD.

Antioxidants & redox signaling - 10 Dec 2016

Cong Weitao, Niu Chao, Lv Lingchun, Ni Maowei, Ruan Dandan, Chi Lisha, Wang Yang, Yu Qing, Zhan Kungao, Xuan Yuanhu, Wang Yuehui, Tan Yi, Wei Tiemin, Cai Lu, Jin Litai

Abstract excerpt

AIMS: Cardiac-specific metallothionein (MT) overexpression extends lifespan, but the mechanism underlying the effect of MT protection against age-associated cardiovascular diseases (CVD) remains elusive. To elucidate this, male wild-type and two lines of MT-transgenic (MT-TG) mice, MM and MT-1 (cardiac-specific overexpressing MT about 10- and 80-fold, respectively) at three representative ages (2-3, 9-10, and...

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Identifiers

PMID: 27477335
DOI: 10.1089/ars.2016.6648
PMCID: PMC5144888

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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