Article
Cardiac myocyte-specific overexpression of human GTP cyclohydrolase I protects against acute cardiac allograft rejection.
American journal of physiology. Heart and circulatory physiology - 1 Jul 2010
Ionova Irina A, Vásquez-Vivar Jeannette, Cooley Brian C, Khanna Ashwani K, Whitsett Jennifer, Herrnreiter Anja, Migrino Raymond Q, Ge Zhi-Dong, Regner Kevin R, Channon Keith M, Alp Nicholas J, Pieper Galen M
Abstract excerpt
GTP cyclohydrolase I (GTPCH) is the rate-limiting enzyme for tetrahydrobiopterin (BH(4)) synthesis. Decreases in GTPCH activity and expression have been shown in late stages of acute cardiac rejection, suggesting a deficit in BH(4). We hypothesized that increasing intracellular levels of BH(4) by cardiac myocyte-targeted overexpression of GTPCH would diminish acute cardiac allograft rejection. Transgenic mice...
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