Article
Sex hormones and cardiomyopathic phenotype induced by cardiac beta 2-adrenergic receptor overexpression.
Endocrinology - 1 Sept 2003
Gao Xiao-Ming, Agrotis Alex, Autelitano Dominic J, Percy Elodie, Woodcock Elizabeth A, Jennings Garry L, Dart Anthony M, Du Xiao-Jun
Abstract excerpt
Sex differences in cardiomyopathic phenotype and the role of gonadal status were studied in mice with cardiac overexpression of beta(2)-adrenergic receptors (ARs) over 6-15 months (mo) of age. Survival to 15 mo was 96% in wild-type mice but was poorer in transgenic (TG) mice and lower for males t...
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