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Article

Age-dependent cardiomyopathy and heart failure phenotype in mice overexpressing beta(2)-adrenergic receptors in the heart.

Cardiovascular research - 1 Dec 2000

Du X J, Gao X M, Wang B, Jennings G L, Woodcock E A, Dart A M

Abstract excerpt

OBJECTIVE: To explore long-term cardiac phenotype in transgenic (TG) mice with 300-fold overexpression of beta(2)-adrenergic receptors (AR). METHODS: Echocardiography was performed serially on a cohort of wild-type and TG mice (n=26 each) between 4 and 15 months of age. Survival was monitored and autopsy and histological examinations were performed. RESULTS: Heart rate was higher in TG than in wild-type mice...

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PMID: 11090840
DOI: 10.1016/s0008-6363(00)00187-5

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