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Article

Increased atherosclerosis and smooth muscle cell hypertrophy in natriuretic peptide receptor A-/-apolipoprotein E-/- mice.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2003

Alexander Matthew R, Knowles Joshua W, Nishikimi Toshio, Maeda Nobuyo

Abstract excerpt

OBJECTIVE: Natriuretic peptide signaling is important in the regulation of blood pressure as well as in the growth of multiple cell types. To examine the role of natriuretic peptide signaling in atherosclerosis, we crossbred mice that lack natriuretic peptide receptor A (NPRA; Npr1-/-) with atherosclerosis-prone mice that lack apolipoprotein E (apoE; Apoe-/-). METHODS AND RESULTS: Doubly deficient Npr1-/-Apoe-/-...

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Identifiers

PMID: 12702516
DOI: 10.1161/01.ATV.0000071702.45741.2E
PMCID: PMC4321898

Genes

NPR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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