Article
Cardiac-specific attenuation of natriuretic peptide A receptor activity accentuates adverse cardiac remodeling and mortality in response to pressure overload.
American journal of physiology. Heart and circulatory physiology - 1 Aug 2005
Patel Jeetendra B, Valencik Maria L, Pritchett Allison M, Burnett John C, McDonald John A, Redfield Margaret M
Abstract excerpt
Atrial (ANP) and brain (BNP) natriuretic peptides are hormones of myocardial cell origin. These hormones bind to the natriuretic peptide A receptor (NPRA) throughout the body, stimulating cGMP production and playing a key role in blood pressure control. Because NPRA receptors are present on cardiomyocytes, we hypothesized that natriuretic peptides may have direct autocrine or paracrine effects on cardiomyocytes...
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