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Article

Early development of calcific aortic valve disease and left ventricular hypertrophy in a mouse model of combined dyslipidemia and type 2 diabetes mellitus.

Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 2014

Le Quang Khai, Bouchareb Rihab, Lachance Dominic, Laplante Marc-André, El Husseini Diala, Boulanger Marie-Chloé, Fournier Dominique, Fang Xiang Ping, Avramoglu Rita Kohen, Pibarot Philippe, Deshaies Yves, Sweeney Gary, Mathieu Patrick, Marette André

Abstract excerpt

OBJECTIVE: This study aimed to determine the potential impact of type 2 diabetes mellitus on left ventricular dysfunction and the development of calcified aortic valve disease using a dyslipidemic mouse model prone to developing type 2 diabetes mellitus. APPROACH AND RESULTS: When compared with nondiabetic LDLr(-/-)/ApoB(100/100), diabetic LDLr(-/-)/ApoB(100/100)/IGF-II mice exhibited similar dyslipidemia and...

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Share to Aortic Valve
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apolipoprotein B-100

Share to Cholesterol, Dietary

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Share to Hypertrophy, Left Ventricular

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Source

Identifiers

PMID: 25231636
DOI: 10.1161/ATVBAHA.114.304205

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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