Article
Cardiovascular functional phenotypes and pharmacological responses in apolipoprotein E deficient mice.
Neurobiology of aging - 1 Mar 2005
Wang Yi-Xin
Abstract excerpt
This is an overview of recent findings, mainly from our laboratory, describing the cardiovascular functional phenotypes and pharmacological responses in mice genetically deficient in apolipoprotein E (apoE-KO). ApoE-KO mice are hyperlipidemic and spontaneously develop atherosclerosis. We have detected several new cardiovascular functional phenotypes in apoE-KO mice: hyperglycemia, age-dependent aortic stiffening,...
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