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Article

Re-evaluating the Impact of Biological Sex on Atherosclerosis in Apoe <sup>−/−</sup> and Ldlr <sup>−/−</sup> mice

2025-09-21

Abstract excerpt

<h4>BACKGROUND</h4> The progression of cardiovascular disease shows significant sexual dimorphism: although females generally develop the disease later in life, they exhibit a higher age-related incidence than males. Despite this clinical pattern, preclinical studies often overlook both sexes in their design, and existing research on sex-specific atherosclerosis in mice remains inconsistent. This study was design...

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Literature Corpus work
b865d9cd-7cf6-5306-b418-035b64a94d60
DOI
10.1101/2025.09.19.677480
Open publication

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