Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Poison domains block transit of translocated substrates via the Legionella pneumophila Icm/Dot system.

Infection and immunity - 1 Sept 2013

Amyot Whitney M, deJesus Dennise, Isberg Ralph R

Abstract excerpt

Legionella pneumophila uses the Icm/Dot type 4B secretion system (T4BSS) to deliver translocated protein substrates to the host cell, promoting replication vacuole formation. The conformational state of the translocated substrates within the bacterial cell is unknown, so we sought to determine if folded substrates could be translocated via this system. Fusions of L. pneumophila Icm/Dot-translocated substrates...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytosol
Share to Legionella pneumophila
Share to Legionnaires' Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Macrophages

Share to Protein Folding

Share to Tetrahydrofolate Dehydrogenase

Share to U937 Cells

Share to Ubiquitin

Source

Open in PubMed Open full text

Identifiers

PMID: 23798536
DOI: 10.1128/IAI.00552-13
PMCID: PMC3754216

Genes

DHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Poison domains block transit of translocated substrates via the Legionella pneumophila Icm/Dot system.PMID 23798536Read ↗

IcmF and DotU are required for optimal effector translocation and trafficking of the Legionella pneumophila vacuole.Semantic proximity Read ↗

The Legionella pneumophila LidA protein: a translocated substrate of the Dot/Icm system associated with maintenance of bacterial integrity.Semantic proximity Read ↗

Legionella effectors that promote nonlytic release from protozoa.Semantic proximity Read ↗

The Coxiella burnetii Dot/Icm system delivers a unique repertoire of type IV effectors into host cells and is required for intracellular replication.Semantic proximity Read ↗

Mechanism of effector capture and delivery by the type IV secretion system from Legionella pneumophila.Semantic proximity Read ↗

The Legionella IcmSW complex directly interacts with DotL to mediate translocation of adaptor-dependent substrates.Semantic proximity Read ↗

Native structure of a type IV secretion system core complex essential for <i>Legionella</i> pathogenesisSemantic proximity Read ↗

The Passage of Chaperonins to Extracellular Locations in Legionella pneumophila Requires a Functional Dot/Icm System.Semantic proximity Read ↗

Rapid escape of the dot/icm mutants of Legionella pneumophila into the cytosol of mammalian and protozoan cells.Semantic proximity Read ↗

Secreted bacterial effectors that inhibit host protein synthesis are critical for induction of the innate immune response to virulent Legionella pneumophila.Semantic proximity Read ↗

Legionella pneumophila DotU and IcmF are required for stability of the Dot/Icm complex.Semantic proximity Read ↗

The Legionella pneumophila IcmS-LvgA protein complex is important for Dot/Icm-dependent intracellular growth.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.