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Article

Using affected sibling pairs to distinguish the direct effect of a susceptibility gene and the indirect effect of linkage disequilibrium.

Annals of human genetics - 1 Mar 2003

Lee W-C

Abstract excerpt

A positive result for a transmission/disequilibrium test (TDT) can occur for two reasons: a) the allele itself is a cause of disease predisposition (direct effect); or b) the allele is in linkage disequilibrium with a disease-causing gene (indirect effect). A test was proposed based on affected sibling pairs (ASPs) to distinguish between the two. Simulation showed that the test has the correct type I error rate...

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Identifiers

PMID: 12675693
DOI: 10.1046/j.1469-1809.2003.00018.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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