Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Detection of vulnerability loci by association and sib-pair methods.

Genetic epidemiology - 1 Jan 1995

Levinson D F

Abstract excerpt

A haplotype-based haplotype relative risk (HHRR) analysis of simulated data for 200 affected offspring and their parents (Genetic Analysis Workshop 9, Problem 1) detected linkage disequilibrium at 2 of 360 marker loci. An additive model was suggested but not proven by haplotypes of affected vs. unaffected offspring. These findings were consistent with the generating model. Affected sib pair analysis failed to...

Topics

Alleles
Case-Control Studies
Chi-Square Distribution
Chromosome Mapping
Computer Simulation
Genetic Markers
Haplotypes
Humans
Linkage Disequilibrium
Models, Genetic
Nuclear Family
Predictive Value of Tests

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Risk Assessment

Source

Identifiers

PMID: 8787985
DOI: 10.1002/gepi.1370120618

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8787985-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Detection of vulnerability loci by association and sib-pair methods.PMID 8787985Read ↗

Linkage analysis of Genetic Analysis Workshop 12 simulated data based on affected individuals only.Semantic proximity Read ↗

Detection of susceptibility loci by genome-wide linkage analysis.Semantic proximity Read ↗

Using affected sibling pairs to distinguish the direct effect of a susceptibility gene and the indirect effect of linkage disequilibrium.Semantic proximity Read ↗

Use of susceptibility scoring in conjunction with the genotypic transmission disequilibrium test.Semantic proximity Read ↗

Two tests of association for a susceptibility locus for families of variable size: an example using two sampling strategies.Semantic proximity Read ↗

Haplotype sharing analysis with SNPs in candidate genes: the Genetic Analysis Workshop 12 example.Semantic proximity Read ↗

Genome scanning for complex disease genes using the transmission/disequilibrium test and haplotype-based haplotype relative risk.Semantic proximity Read ↗

Parametric linkage analysis and disequilibrium methods to identify loci for complex disease.Semantic proximity Read ↗

Genetic analysis workshop 9: development of problem 1.Semantic proximity Read ↗

Investigation of the ability of haplotype association and logistic regression to identify associated susceptibility loci.Semantic proximity Read ↗

Genome screening using extremely discordant and extremely concordant sib pairs.Semantic proximity Read ↗

Investigation into the ability of SNP chipsets and microsatellites to detect association with a disease locus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.