Article
Transmission/disequilibrium test when neither parent is available in some families: a non-iterative approach.
Journal of cancer epidemiology and prevention - 1 Jan 2002
Lee W C
Abstract excerpt
BACKGROUND: The transmission/disequilibrium test (TDT) is a simple method of detecting linkage between a marker locus and a disease-susceptibility locus. The test requires genotype data from the affected individuals (the probands) and their parents, the 'case-parents triads'. However, missing data from parents often complicate the situations. Several non-iterative methods, such as the sibling-based TDT, the...
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