A discordant-sibship test for disequilibrium and linkage: no need for parental data.

doi:10.1086/302137

Back to search

Article

A discordant-sibship test for disequilibrium and linkage: no need for parental data.

American journal of human genetics - 1 Dec 1998

Horvath S, Laird N M

Abstract excerpt

The sibship disequilibrium test (SDT) is designed to detect both linkage in the presence of association and association in the presence of linkage (linkage disequilibrium). The test does not require parental data but requires discordant sibships with at least one affected and one unaffected sibli...

Topics

Alleles
Female
Genetic Linkage
Genetic Markers
Genetic Testing
Genotype
Humans
Linkage Disequilibrium
Male
Nuclear Family
Parents
Sample Size
Statistics, Nonparametric

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.