Article
A discordant-sibship test for disequilibrium and linkage: no need for parental data.
American journal of human genetics - 1 Dec 1998
Horvath S, Laird N M
Abstract excerpt
The sibship disequilibrium test (SDT) is designed to detect both linkage in the presence of association and association in the presence of linkage (linkage disequilibrium). The test does not require parental data but requires discordant sibships with at least one affected and one unaffected sibling. The SDT has many desirable properties: it uses all the siblings in the sibship; it remains valid if there are...
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