General equations for Pt, Ps, and the power of the TDT and the affected-sib-pair test.

doi:10.1016/S0002-9297(07)62965-6

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Article

General equations for Pt, Ps, and the power of the TDT and the affected-sib-pair test.

American journal of human genetics - 1 Nov 2000

McGinnis R

Abstract excerpt

Several equations are highlighted here, whose algebraic symmetries and generality make them very useful for understanding and comparing the properties of the transmission disequilibrium test (TDT) and affected sib-pair test. Methods using the equations are also presented that yield precise estima...

Topics

Alleles
Case-Control Studies
Chromosome Mapping
Humans
Linkage Disequilibrium
Matched-Pair Analysis
Multifactorial Inheritance
Nuclear Family
Polymorphism, Single Nucleotide
Sample Size

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