Article
The transmission/disequilibrium test for linkage on the X chromosome.
American journal of human genetics - 1 Mar 2000
Ho G Y, Bailey-Wilson J E
Abstract excerpt
The transmission/disequilibrium test (TDT), which detects linkage between a marker and disease loci in the presence of linkage disequilibrium, was introduced by Spielman et al. The original TDT requires families in which the genotypes are known for both parents and for at least one affected offspring, and this limits its applicability to diseases with late onset. The sib-TDT, or S-TDT, which utilizes families...
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