Hidden linkage: a comparison of the affected sib pair (ASP) test and transmission/disequilibrium test (TDT).

doi:10.1046/j.1469-1809.1998.6220159.x

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Article

Hidden linkage: a comparison of the affected sib pair (ASP) test and transmission/disequilibrium test (TDT).

Annals of human genetics - 1 Mar 1998

McGinnis R E

Abstract excerpt

I compare the transmission/disequilibrium test (TDT) and affected sib pair (ASP) test under a general algebraic model describing a bi-allelic disease locus. Assuming linkage to a bi-allelic marker, I derive two binomial probabilities, one for parental allele 'transmission' (Pt) which determines t...

Topics

Genetic Diseases, Inborn
Genetic Linkage
Genetic Predisposition to Disease
Humans
Linkage Disequilibrium
Models, Genetic
Models, Statistical
Nuclear Family

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