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Article

Hidden linkage: a comparison of the affected sib pair (ASP) test and transmission/disequilibrium test (TDT).

Annals of human genetics - 1 Mar 1998

McGinnis R E

Abstract excerpt

I compare the transmission/disequilibrium test (TDT) and affected sib pair (ASP) test under a general algebraic model describing a bi-allelic disease locus. Assuming linkage to a bi-allelic marker, I derive two binomial probabilities, one for parental allele 'transmission' (Pt) which determines the magnitude of the TDT chi 2 statistic (chi 2tdt), and a second for identity-by-descent (ibd) marker allele 'sharing'...

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Source

Identifiers

PMID: 9759477
DOI: 10.1046/j.1469-1809.1998.6220159.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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