Article
Use of siblings as controls in case-control association studies.
Annals of human genetics - 1 Jul 1997
Curtis D
Abstract excerpt
The transmission disequilibrium test (TDT) is a simple means to detect association which should only be positive if the marker allele is linked to the disease locus, but it cannot be used if parents of affected subjects are unavailable, as can occur when the disease has a late age of onset. Although one can sometimes deduce parental genotypes using the siblings of affected cases, reliance on this procedure can...
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