Systematic search of susceptibility loci with methods using gametic disequilibrium.

doi:10.1002/gepi.1370120609

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Article

Systematic search of susceptibility loci with methods using gametic disequilibrium.

Genetic epidemiology - 1 Jan 1995

Bickeböller H, Margaritte-Jeannin P, Babron M C, Clerget-Darpoux F

Abstract excerpt

Susceptibility genes are identified for a simulated complex trait by a systematic genome search for linkage between disease and a genetic marker in the presence of gametic disequilibrium. The transmission/disequilibrium tests TDTa or TDTg for multiallelic markers compare transmitted and nontransm...

Topics

Alleles
Chromosome Mapping
Computer Simulation
Genetic Diseases, Inborn
Genetic Markers
Genetic Predisposition to Disease
Genome, Human
Genotype
Haplotypes
Humans
Linkage Disequilibrium

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