Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Involvement of PTEN in airway hyperresponsiveness and inflammation in bronchial asthma.

The Journal of clinical investigation - 1 Apr 2003

Kwak Yong-Geun, Song Chang H, Yi Ho K, Hwang Pyoung H, Kim Jong-Suk, Lee Kyung S, Lee Yong C

Abstract excerpt

Phosphatase and tensin homologue deleted on chromosome ten (PTEN) is part of a complex signaling system that affects a variety of important cell functions. PTEN blocks the action of PI3K by dephosphorylating the signaling lipid phosphatidylinositol 3,4,5-triphosphate. We have used a mouse model for asthma to determine the effect of PI3K inhibitors and PTEN on allergen-induced bronchial inflammation and airway...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Androstadienes
Share to Bronchoalveolar Lavage Fluid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cations

Share to Chromones

Share to Interleukin-5

Share to Methacholine Chloride

Share to Morpholines

Share to Wortmannin

Source

Open in PubMed Open full text

Identifiers

PMID: 12671058
DOI: 10.1172/JCI16440
PMCID: PMC152583

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Involvement of PTEN in airway hyperresponsiveness and inflammation in bronchial asthma.PMID 12671058Read ↗

Conditional deletion of Pten causes bronchiolar hyperplasia.Semantic proximity Read ↗

Pten inactivation accelerates oncogenic K-ras-initiated tumorigenesis in a mouse model of lung cancer.Semantic proximity Read ↗

Akt in the pathogenesis of COPD.Semantic proximity Read ↗

Functional analysis of the tumour suppressor gene PTEN in murine B cells and keratinocytes.Semantic proximity Read ↗

Region-specific role for Pten in maintenance of epithelial phenotype and integrity.Semantic proximity Read ↗

Autoimmunity, intestinal lymphoid hyperplasia, and defects in mucosal B-cell homeostasis in patients with PTEN hamartoma tumor syndrome.Semantic proximity Read ↗

The role of protein tyrosine phosphatases in the regulation of allergic asthma: implication of TC-PTP and PTP-1B in the modulation of disease development.Semantic proximity Read ↗

The loss of PTEN allows TCR alphabeta lineage thymocytes to bypass IL-7 and Pre-TCR-mediated signaling.Semantic proximity Read ↗

Allosteric activation of PTEN phosphatase by phosphatidylinositol 4,5-bisphosphate.Semantic proximity Read ↗

Phosphoinositide 3‐kinase signalling in lung disease: leucocytes and beyondSemantic proximity Read ↗

Ndrg1b and fam49ab modulate the PTEN pathway to control T-cell lymphopoiesis in the zebrafish.Semantic proximity Read ↗

Suppression of a phosphatidylinositol 3-kinase signal by a specific spliced variant of Drosophila PTEN.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.