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Article

Phosphoinositide 3‐kinase signalling in lung disease: leucocytes and beyond

2 Jul 2007

Abstract excerpt

The family of lipid kinases termed phosphoinositide-3-kinase (PI3K) is known to contribute at multiple levels to innate and adaptive immune responses, and is hence an attractive target for drug discovery in inflammatory and autoimmune disease, including respiratory diseases. The development of isoform-selective pharmacological inhibitors, targeted gene manipulation and short interfering RNA (siRNA) target...

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Share to Cytokine Signaling Pathways and Interactions
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PMID: 17614878
DOI: 10.1111/j.1365-2567.2007.02663.x

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