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Article

Allosteric activation of PTEN phosphatase by phosphatidylinositol 4,5-bisphosphate.

The Journal of biological chemistry - 5 Sept 2003

Campbell Robert B, Liu Fenghua, Ross Alonzo H

Abstract excerpt

Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a tumor suppressor that is lost in many human tumors and encodes a phosphatidylinositol phosphate phosphatase specific for the 3-position of the inositol ring. Here we report a novel mechanism of PTEN regulation. Binding of di-C8...

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Source

Identifiers

PMID: 12857747
DOI: 10.1074/jbc.C300296200

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12857747-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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