Article
Suppression of a phosphatidylinositol 3-kinase signal by a specific spliced variant of Drosophila PTEN.
FEBS letters - 7 May 2004
Maehama Tomohiko, Kosaka Natsuki, Okahara Fumiaki, Takeuchi Ken-ichi, Umeda Masato, Dixon Jack E, Kanaho Yasunori
Abstract excerpt
Drosophila PTEN (dPTEN) plays indispensable roles in the development of Drosophila melanogaster by controlling cell size and number. Although three potential spliced forms of dPTEN have been isolated, functional distinction among these forms remains elusive. In this study, we demonstrate that all spliced forms of dPTEN dephosphorylate phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P(3)); however,...
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