Article
Akt in the pathogenesis of COPD.
International journal of chronic obstructive pulmonary disease - 1 Jan 2006
Bozinovski Steven, Vlahos Ross, Hansen Michelle, Liu Ken, Anderson Gary P
Abstract excerpt
In this review we consider the therapeutic potential of targeting Akt for the treatment of COPD. Akt is a serine/threonine protein kinase that functions as a signaling intermediate linked to multiple signaling programs involved in survival, inflammation, and growth. Akt is closely associated with key membrane-bound receptors and represents a convergent integration point for multiple stimuli implicated in COPD...
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