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Article

Region-specific role for Pten in maintenance of epithelial phenotype and integrity.

American journal of physiology. Lung cellular and molecular physiology - 1 Jan 2017

Flodby Per, Liebler Janice M, Sunohara Mitsuhiro, Castillo Dan R, McConnell Alicia M, Krishnaveni Manda S, Banfalvi Agnes, Li Min, Stripp Barry, Zhou Beiyun, Crandall Edward D, Minoo Parviz, Borok Zea

Abstract excerpt

Previous studies have demonstrated resistance to naphthalene-induced injury in proximal airways of mice with lung epithelial-specific deletion of the tumor-suppressor gene Pten, attributed to increased proliferation of airway progenitors. We tested effects of Pten loss following bleomycin injury, a model typically used to study distal lung epithelial injury, in conditional PtenSFTPC-cre knockout mice....

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Identifiers

PMID: 27864284
DOI: 10.1152/ajplung.00005.2015
PMCID: PMC5283927

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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