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Article

Physiological studies in heterozygous calcium sensing receptor (CaSR) gene-ablated mice confirm that the CaSR regulates calcitonin release in vivo.

BMC physiology - 20 Apr 2004

Fudge Neva J, Kovacs Christopher S

Abstract excerpt

BACKGROUND: The calcium sensing receptor (CaSR) regulates serum calcium by suppressing secretion of parathyroid hormone; it also regulates renal tubular calcium excretion. Inactivating mutations of CaSR raise serum calcium and reduce urine calcium excretion. Thyroid C-cells (which make calcitonin) express CaSR and may, therefore, be regulated by it. Since calcium stimulates release of calcitonin, the higher blood...

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Identifiers

PMID: 15099400
DOI: 10.1186/1472-6793-4-5
PMCID: PMC419359

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