Article
Parathyroid-specific double knockout of Gq and G11 alpha-subunits leads to a phenotype resembling germline knockout of the extracellular Ca2+ -sensing receptor.
Molecular endocrinology (Baltimore, Md.) - 1 Jan 2007
Wettschureck Nina, Lee EunAh, Libutti Steven K, Offermanns Stefan, Robey Pamela G, Spiegel Allen M
Abstract excerpt
Germline knockout of the extracellular Ca2+ -sensing receptor (CaR) leads to a phenotype that includes severe hypercalcemia, hyperparathyroidism, relative hypocalciuria, skeletal abnormalities, retarded growth, and early postnatal death. To investigate the role of heterotrimeric G proteins in CaR signaling, we used cre/lox technology to delete the respective alpha-subunits of Gq and G11 selectively in parathyroid...
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