Article
The full-length calcium-sensing receptor dampens the calcemic response to 1alpha,25(OH)2 vitamin D3 in vivo independently of parathyroid hormone.
American journal of physiology. Renal physiology - 1 Sept 2009
Egbuna Ogo, Quinn Steven, Kantham Lakshmi, Butters Robert, Pang Jiang, Pollak Martin, Goltzman David, Brown Edward
Abstract excerpt
1Alpha,25(OH)(2) vitamin D(3) [1,25(OH)(2)D(3)] increases serum Ca(2+) concentration in vivo, an action counteracted by activation of the Ca(2+)-sensing receptor (CaSR), which decreases parathyroid hormone (PTH) secretion and increases renal Ca(2+) excretion. Relatively little is known of the role the CaSR plays in this response through its potentially direct actions in kidney, gut, and bone independently of PTH....
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