Article
The role of the calcium-sensing receptor in human disease.
Clinical biochemistry - 1 Aug 2012
Ward Bryan K, Magno Aaron L, Walsh John P, Ratajczak Thomas
Abstract excerpt
Following the discovery of the calcium-sensing receptor (CaSR) in 1993, its pivotal role in disorders of calcium homeostasis such as Familial Hypocalciuric Hypercalcemia (FHH) was quickly demonstrated. Since then, it has become clear that the CaSR has immense functional versatility largely through its ability to activate many different signaling pathways in a ligand- and tissue-specific manner. This allows the...
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