Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Monoallelic up-regulation of the imprinted H19 gene in airway epithelium of phenotypically normal cigarette smokers.

Cancer research - 1 Apr 2003

Kaplan Rana, Luettich Karsta, Heguy Adriana, Hackett Neil R, Harvey Ben-Gary, Crystal Ronald G

Abstract excerpt

H19, a paternally imprinted gene, is postulated to have regulatory functions in normal development and oncogenesis. Loss of imprinting (LOI) of H19 is observed in human malignancies, including lung cancer. Microarray assessment of gene expression patterns in airway epithelium of healthy 20 pack-year smokers versus nonsmokers revealed that smokers have dramatically elevated H19 RNA levels without alteration of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bronchi
Share to Genomic Imprinting

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oligonucleotide Array Sequence Analysis

Share to Respiratory Mucosa

Share to RNA, Long Noncoding

Share to RNA, Untranslated

Share to Smoking

Share to Up-Regulation

Source

Identifiers

PMID: 12670893

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Monoallelic up-regulation of the imprinted H19 gene in airway epithelium of phenotypically normal cigarette smokers.PMID 12670893Read ↗

H19 lncRNA: Roles in tumorigenesis.Semantic proximity Read ↗

The product of the imprinted H19 gene is an oncofetal RNA.Semantic proximity Read ↗

Imprinted H19 gene expression in embryogenesis and human cancer: the oncofetal connection.Semantic proximity Read ↗

The H19 Long non-coding RNA in cancer initiation, progression and metastasis – a proposed unifying theorySemantic proximity Read ↗

Monoallelic expression of the human H19 gene.Semantic proximity Read ↗

The c-Myc oncogene directly induces the H19 noncoding RNA by allele-specific binding to potentiate tumorigenesis.Semantic proximity Read ↗

Imprinted expression and methylation of the mouse H19 gene are conserved in extraembryonic lineages.Semantic proximity Read ↗

The transcriptional status but not the imprinting control region determines allele-specific histone modifications at the imprinted H19 locus.Semantic proximity Read ↗

Frequent loss of imprinting at the IGF2 and H19 genes in head and neck squamous carcinomaSemantic proximity Read ↗

The imprinted H19 lncRNA antagonizes let-7 microRNAs.Semantic proximity Read ↗

The prevalence of loss of imprinting of H19 and IGF2 at birth.Semantic proximity Read ↗

The H19 Gene Imprinting in Normal Pregnancy and Pre-eclampsiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.