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Article

The c-Myc oncogene directly induces the H19 noncoding RNA by allele-specific binding to potentiate tumorigenesis.

Cancer research - 15 May 2006

Barsyte-Lovejoy Dalia, Lau Suzanne K, Boutros Paul C, Khosravi Fereshteh, Jurisica Igor, Andrulis Irene L, Tsao Ming S, Penn Linda Z

Abstract excerpt

The product of the MYC oncogene is widely deregulated in cancer and functions as a regulator of gene transcription. Despite an extensive profile of regulated genes, the transcriptional targets of c-Myc essential for transformation remain unclear. In this study, we show that c-Myc significantly induces the expression of the H19 noncoding RNA in diverse cell types, including breast epithelial, glioblastoma, and...

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Source

Identifiers

PMID: 16707459
DOI: 10.1158/0008-5472.CAN-06-0037

Genes

IGF2
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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