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Article

The imprinted H19 lncRNA antagonizes let-7 microRNAs.

Molecular cell - 10 Oct 2013

Kallen Amanda N, Zhou Xiao-Bo, Xu Jie, Qiao Chong, Ma Jing, Yan Lei, Lu Lingeng, Liu Chaochun, Yi Jae-Sung, Zhang Haifeng, Min Wang, Bennett Anton M, Gregory Richard I, Ding Ye, Huang Yingqun

Abstract excerpt

Abundantly expressed in fetal tissues and adult muscle, the developmentally regulated H19 long noncoding RNA (lncRNA) has been implicated in human genetic disorders and cancer. However, how H19 acts to regulate gene function has remained enigmatic, despite the recent implication of its encoded miR-675 in limiting placental growth. We noted that vertebrate H19 harbors both canonical and noncanonical binding sites...

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Share to Databases, Genetic
Share to Genomic Imprinting

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Human Umbilical Vein Endothelial Cells

Share to Muscle Development

Share to Myoblasts, Skeletal

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Identifiers

PMID: 24055342
DOI: 10.1016/j.molcel.2013.08.027
PMCID: PMC3843377

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