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The H19 Long non-coding RNA in cancer initiation, progression and metastasis – a proposed unifying theory

4 Nov 2015

Abstract excerpt

The imprinted oncofetal long non-coding RNA (lncRNA) H19 is expressed in the embryo, down-regulated at birth and then reappears in tumors. Its role in tumor initiation and progression has long been a subject of controversy, although accumulating data suggest that H19 is one of the major genes in cancer. It is actively involved in all stages of tumorigenesis and is expressed in almost every human cancer. In this...

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PMID: 26536864
DOI: 10.1186/s12943-015-0458-2

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