Article
The transcriptional status but not the imprinting control region determines allele-specific histone modifications at the imprinted H19 locus.
Molecular and cellular biology - 1 Jan 2008
Verona Raluca I, Thorvaldsen Joanne L, Reese Kimberly J, Bartolomei Marisa S
Abstract excerpt
Genomic imprinting governs allele-specific gene expression in an epigenetically heritable manner. The characterization of histone modifications at imprinted gene loci is incomplete, and whether specific histone marks determine transcription or are dependent on it is not understood. Using chromatin immunoprecipitations, we examined in multiple cell types and in an allele-specific manner the active and repressive...
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