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Article

Effect of the Asp298 variant of endothelial nitric oxide synthase on survival for patients with congestive heart failure.

Circulation - 1 Apr 2003

McNamara Dennis M, Holubkov Richard, Postava Lisa, Ramani Ravi, Janosko Karen, Mathier Michael, MacGowan Guy A, Murali Srinivas, Feldman Arthur M, London Barry

Abstract excerpt

BACKGROUND: Significant variation exists within the endothelial nitric oxide synthase (NOS3) gene that may influence cardiovascular risk. The Asp298 variant of NOS3 has a shorter half-life in endothelial cells. Given the importance of nitric oxide in the heart failure syndrome, we evaluated the effect of this variant on event-free survival in a population with systolic dysfunction. METHODS AND RESULTS: Four...

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Source

Identifiers

PMID: 12668492
DOI: 10.1161/01.CIR.0000060540.93836.AA

Genes

NOS3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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