Article
Endothelial nitric oxide synthase (NOS3) polymorphisms in African Americans with heart failure: results from the A-HeFT trial.
Journal of cardiac failure - 1 Apr 2009
McNamara Dennis M, Tam S William, Sabolinski Michael L, Tobelmann Page, Janosko Karen, Venkitachalam Lakshmi, Ofili Elizabeth, Yancy Clyde, Feldman Arthur M, Ghali Jalal K, Taylor Anne L, Cohn Jay N, Worcel Manuel
Abstract excerpt
BACKGROUND: Genetic heterogeneity at the endothelial nitric oxide synthase (NOS3) locus influences heart failure outcomes. The prevalence of NOS3 variants differs in black and white cohorts, but the impact of these differences is unknown. METHODS AND RESULTS: Subjects (n = 352) in the Genetic Risk Assessment of Heart Failure (GRAHF) substudy of the African-American Heart Failure Trial were genotyped for NOS3...
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