Article
A promoter polymorphism of the endothelial nitric oxide synthase gene is associated with reduced mRNA and protein expression in failing human myocardium.
Journal of cardiac failure - 1 Apr 2010
Doshi Amit A, Ziolo Mark T, Wang Honglan, Burke Emily, Lesinski Amanda, Binkley Philip
Abstract excerpt
BACKGROUND: Alterations of endothelial nitric oxide synthase (eNOS) enzyme activity via eNOS gene polymorphisms have been associated with significant cardiovascular morbidity and mortality. Both the thymidine to cytosine transition mutation (T(-786)-->C) in the promoter region and the missense mutation in the exon 7 coding region of the eNOS gene (G(894)-->T) have been associated with several cardiovascular...
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