Article
Polymorphisms of endothelial nitric oxide synthase gene in systolic heart failure: an haplotype analysis.
Nitric oxide : biology and chemistry - 31 Mar 2012
Martinelli Nidiane C, Santos Kátia G, Biolo Andréia, La Porta Vanessa L, Cohen Carolina R, Silvello Daiane, Andrades Michael E, Clausell Nadine, Rohde Luis E
Abstract excerpt
BACKGROUND: Endothelial nitric oxide synthase (eNOS) gene polymorphisms have been associated with the pathogenesis of cardiovascular diseases, but few studies have evaluated the role of eNOS haplotypes on the risk and prognosis of heart failure (HF). This prospective study was designed to analyze the impact of three eNOS polymorphisms (T-786C, VNTR4a/b and Glu298Asp) and their haplotypes on the susceptibility and...
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