Article
p27kip1 in intestinal tumorigenesis and chemoprevention in the mouse.
Cancer research - 15 Oct 2005
Yang Wancai, Bancroft Laura, Liang Jiao, Zhuang Min, Augenlicht Leonard H
Abstract excerpt
Targeted inactivation of p27(kip1) was sufficient for intestinal tumor formation in mice, but this was strictly a function of diet: tumors formed in p27(+/-) or p27(-/-) mice fed control AIN-76A diet and were increased by a western-style diet but did not develop in mice fed standard chow diet. When crossed with the Apc1638N(+/-) mouse, Apc(+/-),p27(+/-) or Apc(+/-),p27(-/-) mice not only formed twice as many...
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