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Suppression of Familial Adenomatous Polyposis by CP-31398, a TP53 Modulator, in <i>APCmin/+</i> Mice

14 Sept 2008

Abstract excerpt

p53 mutations occur in a large number of human malignancies. Mutant p53 is unable to affect downstream genes necessary for DNA repair, cell cycle regulation, and apoptosis. The styrylquinazoline CP-31398 can rescue destabilized mutant p53 expression and promote activity of wild-type p53. The present study examines chemopreventive effects of CP-31398 on intestinal adenoma development in an animal model of familial...

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PMID: 18794156
DOI: 10.1158/0008-5472.can-08-1610

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