Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Silibinin suppresses spontaneous tumorigenesis in APC min/+ mouse model by modulating beta-catenin pathway.

Pharmaceutical research - 1 Dec 2009

Rajamanickam Subapriya, Kaur Manjinder, Velmurugan Balaiya, Singh Rana P, Agarwal Rajesh

Abstract excerpt

PURPOSE: Here we assessed whether silibinin, a nontoxic chemopreventive agent, inhibits spontaneous intestinal tumorigenesis in APC ( min/+) mouse model, a genetically predisposed animal model of human familial adenomatous polyposis (FAP). MATERIALS AND METHODS: Six-week-old APC (min/+) mice were divided into four groups and orally gavaged with 0.2 ml vehicle, or 250, 500 and 750 mg silibinin/kg body weight in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenomatous Polyposis Coli Protein
Share to Antioxidants

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to beta Catenin

Share to Cell Proliferation

Share to Disease Models, Animal

Share to Dose-Response Relationship, Drug

Share to Immunohistochemistry

Share to Intestinal Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 19779968
DOI: 10.1007/s11095-009-9968-1
PMCID: PMC2809789

Genes

APC
FAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Silibinin suppresses spontaneous tumorigenesis in APC min/+ mouse model by modulating beta-catenin pathway.PMID 19779968Read ↗

Suppression of Familial Adenomatous Polyposis by CP-31398, a TP53 Modulator, in <i>APCmin/+</i> MiceSemantic proximity Read ↗

Irsogladine maleate, a gastric mucosal protectant, suppresses intestinal polyp development in Apc-mutant mice.Semantic proximity Read ↗

Tgfbr1 Haploinsufficiency Is a Potent Modifier of Colorectal Cancer DevelopmentSemantic proximity Read ↗

Chemoprevention of spontaneous intestinal adenomas in the Apc Min mouse model by the nonsteroidal anti-inflammatory drug piroxicam.Semantic proximity Read ↗

Chemopreventive efficacy and pharmacokinetics of curcumin in the min/+ mouse, a model of familial adenomatous polyposis.Semantic proximity Read ↗

Intestinal tumours induced by the food carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in multiple intestinal neoplasia mice have truncation mutations as well as loss of the wild-type Apc(+) allele.Semantic proximity Read ↗

The antimicrobial metabolite nisin Z reduces intestinal tumorigenesis and modulates the cecal microbiome in Apc <sup>Min/+</sup> miceSemantic proximity Read ↗

Suppression of intestinal carcinogenesis in Apc-mutant mice by limoninSemantic proximity Read ↗

Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposisSemantic proximity Read ↗

Multistep carcinogenesis of the colon in Apc(Min/+) mouse.Semantic proximity Read ↗

Fas/CD95 Deficiency in ApcMin/+ Mice Increases Intestinal Tumor BurdenSemantic proximity Read ↗

Intestinal-specific PPARgamma deficiency enhances tumorigenesis in ApcMin/+ mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.