Article
Erk activation is required for Nrf2 nuclear localization during pyrrolidine dithiocarbamate induction of glutamate cysteine ligase modulatory gene expression in HepG2 cells.
Toxicological sciences : an official journal of the Society of Toxicology - 1 May 2003
Zipper Laurie M, Mulcahy R Timothy
Abstract excerpt
Pyrrolidine dithiocarbamate (PDTC) induction of the human glutamate cysteine ligase modulatory (GCLM) gene is dependent on activation of the mitogen-activated protein kinases (MAPKs) extracellular regulated kinase (Erk) and p38, and is not affected by protein kinase C (PKC) or PI3K inhibitors. Nrf2 binding to the electrophile response element (EpRE) located within the GCLM promoter is decreased after MAPK...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.