Article
Alkylating Agent-Induced NRF2 Blocks Endoplasmic Reticulum Stress-Mediated Apoptosis via Control of Glutathione Pools and Protein Thiol Homeostasis.
Molecular cancer therapeutics - 1 Dec 2016
Zanotto-Filho Alfeu, Masamsetti V Pragathi, Loranc Eva, Tonapi Sonal S, Gorthi Aparna, Bernard Xavier, Gonçalves Rosângela Mayer, Moreira José C F, Chen Yidong, Bishop Alexander J R
Abstract excerpt
Alkylating agents are a commonly used cytotoxic class of anticancer drugs. Understanding the mechanisms whereby cells respond to these drugs is key to identify means to improve therapy while reducing toxicity. By integrating genome-wide gene expression profiling, protein analysis, and functional cell validation, we herein demonstrated a direct relationship between NRF2 and Endoplasmic Reticulum (ER) stress...
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