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Article

Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression.

The Journal of biological chemistry - 22 Nov 2002

Sasaki Hiromi, Sato Hideyo, Kuriyama-Matsumura Kazumi, Sato Kanako, Maebara Kanako, Wang Hongyu, Tamba Michiko, Itoh Ken, Yamamoto Masayuki, Bannai Shiro

Abstract excerpt

In mammalian cultured cells, the cystine/glutamate exchange transport mediated by system x(c)- is important to maintain intracellular GSH levels. System x(c)- consists of two protein components, xCT and the heavy chain of 4F2 antigen. The activity of system x(c)- is induced by various stimuli, including electrophilic agents like diethyl maleate. In the present study, we have investigated the mechanism of the...

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PMID: 12235164
DOI: 10.1074/jbc.M208704200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression.PMID 12235164Read ↗

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