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Article

Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity.

Molecular and cellular biology - 1 Apr 2008

Yamamoto Tae, Suzuki Takafumi, Kobayashi Akira, Wakabayashi Junko, Maher Jon, Motohashi Hozumi, Yamamoto Masayuki

Abstract excerpt

Keap1 and Cul3 constitute a unique ubiquitin E3 ligase that degrades Nrf2, a key activator of cytoprotective genes. Upon exposure to oxidants/electrophiles, the enzymatic activity of this ligase complex is inhibited and the complex fails to degrade Nrf2, resulting in the transcriptional activation of Nrf2 target genes. Keap1 possesses several reactive cysteine residues that covalently bond with electrophiles in...

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Identifiers

PMID: 18268004
DOI: 10.1128/MCB.01704-07
PMCID: PMC2293100

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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