Article
Activation of the Nrf2/ARE pathway via S-alkylation of cysteine 151 in the chemopreventive agent-sensor Keap1 protein by falcarindiol, a conjugated diacetylene compound.
Toxicology and applied pharmacology - 1 Apr 2010
Ohnuma Tomokazu, Nakayama Shinji, Anan Eisaburo, Nishiyama Takahito, Ogura Kenichiro, Hiratsuka Akira
Abstract excerpt
Under basal conditions, the interaction of the cytosolic protein Kelch-like ECH-associated protein 1 (Keap1) with the transcription factor nuclear factor-E2-related factor 2 (Nrf2) results in a low level of expression of cytoprotective genes whose promoter region contains the antioxidant response element (ARE). In response to oxidants and electrophiles, Nrf2 is stabilized and accumulates in the nucleus. The...
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