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Article

Expression of xCT and activity of system xc− are regulated by NRF2 in human breast cancer cells in response to oxidative stress

26 Mar 2015

Abstract excerpt

Cancer cells adapt to high levels of oxidative stress in order to survive and proliferate by activating key transcription factors. One such master regulator, the redox sensitive transcription factor NF E2 Related Factor 2 (NRF2), controls the expression of cellular defense genes including those encoding intracellular redox-balancing proteins involved in glutathione (GSH) synthesis. Under basal conditions,...

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Share to Cardiovascular, Neuropeptides, and Oxidative Stress Research
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PMID: 25827424
DOI: 10.1016/j.redox.2015.03.003

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