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Article

Regulation of gamma-glutamylcysteine synthetase subunit gene expression by the transcription factor Nrf2.

The Journal of biological chemistry - 19 Nov 1999

Wild A C, Moinova H R, Mulcahy R T

Abstract excerpt

Exposure of HepG2 cells to beta-naphthoflavone (beta-NF) or pyrrolidine dithiocarbamate (PDTC) resulted in the up-regulation of the gamma-glutamylcysteine synthetase catalytic (GCS(h)) and regulatory (GCS(l)) subunit genes. Increased expression was associated with an increase in the binding of Nrf2 to electrophile response elements (EpRE) in the promoters of these genes. Nrf2 overexpression increased the activity...

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Share to Gene Expression Regulation, Enzymologic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10559251
DOI: 10.1074/jbc.274.47.33627

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Regulation of gamma-glutamylcysteine synthetase subunit gene expression by the transcription factor Nrf2.PMID 10559251Read ↗

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