Article
Results of p53 analysis in pediatric malignancies in Poland.
Medical and pediatric oncology - 1 May 2003
Fiszer-Maliszewska Łucja, Czernik Jerzy, Sawicz-Birkowska Krystyna, Kazanowska Bernarda, Wojciechowska Beata
Abstract excerpt
BACKGROUND: Mutations of the p53 gene are thought to be causally associated with the development of various neoplasms. In tumors overexpressing the wild-form of p53, its functional inactivation has been suggested, and MDM2 seems to be important in this process. We analyzed p53 in childhood solid tumors, as data on pediatric malignancies are still limited. PROCEDURE: The p53 gene was screened for mutations by the...
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