Article
p53 gene analysis in childhood B non-Hodgkin's lymphoma.
Sao Paulo medical journal = Revista paulista de medicina - 1 Nov 2001
Klumb C E, de Resende L M, Tajara E H, Bertelli E C, Rumjanek V M, Maia R C
Abstract excerpt
CONTEXT: Mutations or deletions in the tumor-suppressor gene p53 are among the commonest genetic changes found in human neoplasms including breast, lung and bowel cancers. In hematological malignancies, p53 is most often mutated in Burkitt's lymphoma, with p53 mutations present in 30 to 40% of tumor samples and in 70% of cell lines. OBJECTIVE: To analyze the p53 gene alterations in child patients with B...
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